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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-25
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pubmed:abstractText |
New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a, b and 12a, d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1520-4804
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5135-9
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pubmed:meshHeading |
pubmed-meshheading:18666770-Antineoplastic Agents,
pubmed-meshheading:18666770-Benzopyrans,
pubmed-meshheading:18666770-Benzothiazoles,
pubmed-meshheading:18666770-Benzoxazoles,
pubmed-meshheading:18666770-Breast Neoplasms,
pubmed-meshheading:18666770-Cell Cycle,
pubmed-meshheading:18666770-Cell Line, Tumor,
pubmed-meshheading:18666770-Humans,
pubmed-meshheading:18666770-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:18666770-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648).
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pubmed:affiliation |
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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