| pubmed-article:18664571 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0013117 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0872078 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C1825644 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18664571 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18664571 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:18664571 | pubmed:dateCreated | 2008-10-6 | lld:pubmed |
| pubmed-article:18664571 | pubmed:abstractText | The Ca(2+)-binding protein DREAM regulates gene transcription and Kv potassium channels in neurons but has also been claimed to interact with presenilins, which are involved in the generation of beta-amyloid and in the regulation of the Ca(2+) content in the endoplasmic reticulum. The role of DREAM in Ca(2+) homeostasis was thus explored in SH-SY5Y cells stably or transiently overexpressing DREAM or a Ca(2+)-insensitive mutant of it. The overexpression of DREAM had transcriptional and post-transcriptional effects. Endoplasmic reticulum Ca(2+) and capacitative Ca(2+) influx were reduced in stably expressing cells. The previously shown down-regulation of Na(+)/Ca(2+) exchanger 3 expression was confirmed; it could cause a local increase of subplasma membrane Ca(2+) and thus inhibit capacitative Ca(2+) influx. DREAM up-regulated the expression of the inositol 1,4,5-trisphosphate receptor and could thus increase the unstimulated release of Ca(2+) through it. The transient coexpression of DREAM and presenilin potentiated the decrease of endoplasmic reticulum Ca(2+) observed in presenilin-overexpressing cells. This could be due to a direct effect of DREAM on presenilin as the two proteins interacted in a Ca(2+)-independent fashion. | lld:pubmed |
| pubmed-article:18664571 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18664571 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664571 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18664571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18664571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664571 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18664571 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18664571 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18664571 | pubmed:author | pubmed-author:CarafoliErnes... | lld:pubmed |
| pubmed-article:18664571 | pubmed:author | pubmed-author:BriniMarisaM | lld:pubmed |
| pubmed-article:18664571 | pubmed:author | pubmed-author:LimDmitryD | lld:pubmed |
| pubmed-article:18664571 | pubmed:author | pubmed-author:FedrizziLaura... | lld:pubmed |
| pubmed-article:18664571 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18664571 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18664571 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18664571 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18664571 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18664571 | pubmed:pagination | 27494-503 | lld:pubmed |
| pubmed-article:18664571 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18664571 | pubmed:meshHeading | pubmed-meshheading:18664571... | lld:pubmed |
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| pubmed-article:18664571 | pubmed:meshHeading | pubmed-meshheading:18664571... | lld:pubmed |
| pubmed-article:18664571 | pubmed:meshHeading | pubmed-meshheading:18664571... | lld:pubmed |
| pubmed-article:18664571 | pubmed:meshHeading | pubmed-meshheading:18664571... | lld:pubmed |
| pubmed-article:18664571 | pubmed:meshHeading | pubmed-meshheading:18664571... | lld:pubmed |
| pubmed-article:18664571 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18664571 | pubmed:articleTitle | Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling. | lld:pubmed |
| pubmed-article:18664571 | pubmed:affiliation | Department of Biochemistry, University of Padova, Padova 35131, Italy. | lld:pubmed |
| pubmed-article:18664571 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18664571 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:30818 | entrezgene:pubmed | pubmed-article:18664571 | lld:entrezgene |
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