18655037

Source:http://linkedlifedata.com/resource/pubmed/id/18655037

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205263, umls-concept:C0806140, umls-concept:C1450054
pubmed:issue	14
pubmed:dateCreated	2008-7-29
pubmed:abstractText	We present an approach for the accumulation and filtering of nano- and microparticles in microfluidic devices that is based on the generation of electric traveling waves in the radio-frequency range. Upon application of the electric field via a microelectrode array, complex particle trajectories and particle accumulation are observed in well-defined regions in a microchannel. Through the quantitative mapping of the 3-D flow pattern using two-focus fluorescence cross-correlation spectroscopy, two vortices could be identified as one of the sources of the force field that induces the formation of particle clouds. Dielectrophoretic forces that directly act on the particles are the second source of the force field. A thorough 2-D finite element analysis identifies the electric traveling wave mechanism as the cause for the unexpected flow behavior observed. Based on these findings, strategies are discussed, first, for avoiding the vortices to optimize electrohydrodynamic micropumps and, secondly, for utilizing the vortices in the development of microdevices for efficient particle accumulation, separation, and filtering. Such devices may find numerous biomedical applications when highly diluted nano- and microsuspensions have to be processed.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8204476
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0173-0835
pubmed:author	pubmed-author:DuschlClausC, pubmed-author:FeltenMaikaM, pubmed-author:JaegerMagnus SMS, pubmed-author:SchwillePetraP, pubmed-author:StaroskeWolfgangW
pubmed:issnType	Print
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2987-96
pubmed:meshHeading	pubmed-meshheading:18655037-Electrophoresis, Microchip, pubmed-meshheading:18655037-Microfluidics, pubmed-meshheading:18655037-Nanoparticles
pubmed:year	2008
pubmed:articleTitle	Accumulation and filtering of nanoparticles in microchannels using electrohydrodynamically induced vortical flows.
pubmed:affiliation	Department of Biotechnology and Medical Technology, Saarland University Hospital, Homburg/Saar, Germany.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't