Linked Life Data

18651158

Source:http://linkedlifedata.com/resource/pubmed/id/18651158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-11-12
pubmed:abstractText
Chromosomes occupy non-random spatial positions in interphase nuclei. It remains unclear what orchestrates this high level of organisation. To determine how the nuclear environment influences the spatial positioning of chromosomes, we utilised a panel of stable mouse hybrid cell lines carrying a single, intact human chromosome. Eleven of 22 human chromosomes revealed an alternative location in hybrid nuclei compared to that of human fibroblasts, with the majority becoming more internally localised. Human chromosomes in mouse nuclei position according to neither their gene density nor size, but rather the position of human chromosomes in hybrid nuclei appears to mimic that of syntenic mouse chromosomes. These results suggest that chromosomes adopt the behaviour of their host species chromosomes and that the nuclear environment is an important determinant of the interphase positioning of chromosomes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1432-0886
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-91
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Positioning of human chromosomes in murine cell hybrids according to synteny.
pubmed:affiliation
Laboratory of Nuclear and Genomic Health, Centre for Cell & Chromosome Biology, Biosciences School of Health Sciences & Social Care, Brunel University, Uxbridge, Middlesex UB8 3PH, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't