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rdf:type |
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lifeskim:mentions |
umls-concept:C0061467,
umls-concept:C0205314,
umls-concept:C0205464,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243072,
umls-concept:C0243077,
umls-concept:C0439611,
umls-concept:C0521390,
umls-concept:C0679622,
umls-concept:C1420119,
umls-concept:C1883254
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-18
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pubmed:abstractText |
A series of beta-benzylaspartate derivatives were prepared from N-trityl-L-aspartate dimethyl ester and evaluated as inhibitors of neuronal glutamate transporter EAAT3. The result of the structure-activity studies suggests that the position occupied by the aromatic ring of beta-benzylaspartate within the binding site of EAAT3 may be different from that occupied by comparable groups in previously identified inhibitors, such as L-threo-benzyloxy aspartate (TBOA). Further, halogen substitutions at the 3-position of the aromatic ring of beta-benzylaspartate can increase the potency with which the analogues inhibit EAAT3.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-11078189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-11369436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-11709060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-14624363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-15044631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-15234100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-16112332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-16377242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-17088867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-17230192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-17901324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650095-8857541
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7740-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3.
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pubmed:affiliation |
NIH-COBRE Center for Structural and Functional Neuroscience, Department of Biomedical & Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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