| pubmed-article:18640985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0167627 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0443299 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C1707076 | lld:lifeskim |
| pubmed-article:18640985 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18640985 | pubmed:issue | 37 | lld:pubmed |
| pubmed-article:18640985 | pubmed:dateCreated | 2008-9-8 | lld:pubmed |
| pubmed-article:18640985 | pubmed:abstractText | We report a role for CA repeats in the 3'-untranslated region (3'-UTR) in regulating CD154 expression. Human CD154 is encoded by an unstable mRNA; this instability is conferred in cis by a portion of its 3'-UTR that includes a polypyrimidine-rich region and CA dinucleotide repeat. We demonstrate similar instability activity with the murine CD154 3'-UTR. This instability element mapped solely to a conserved 100-base CU-rich region alone, which we call a CU-rich response element. Surprisingly, the CA dinucleotide-rich region also regulated reporter expression but at the level of translation. This activity was associated with poly(A) tail shortening and regulated by heterogeneous nuclear ribonucleoprotein L levels. We conclude that the CD154 3'-UTR contains dual cis-acting elements, one of which defines a novel function for exonic CA dinucleotide repeats. These findings suggest a mechanism for the association of 3'-UTR CA-rich response element polymorphisms with CD154 overexpression and the subsequent risk of autoimmune disease. | lld:pubmed |
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| pubmed-article:18640985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18640985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18640985 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18640985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18640985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18640985 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18640985 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:ShuQ SQS | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:MoulandAndrew... | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:RigbyWilliam... | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:HamiltonB... | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:HenryBrianB | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:WangXiao-WeiX... | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:BlochDonaldD | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:CollinsJaneJ | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:TerryBenjamin... | lld:pubmed |
| pubmed-article:18640985 | pubmed:author | pubmed-author:BergeronAlanA | lld:pubmed |
| pubmed-article:18640985 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18640985 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:18640985 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18640985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18640985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18640985 | pubmed:pagination | 25606-16 | lld:pubmed |
| pubmed-article:18640985 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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