Source:http://linkedlifedata.com/resource/pubmed/id/18632190
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-2-23
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pubmed:abstractText |
A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1768-3254
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
891-900
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pubmed:meshHeading |
pubmed-meshheading:18632190-Antineoplastic Agents,
pubmed-meshheading:18632190-Cell Line, Tumor,
pubmed-meshheading:18632190-Drug Screening Assays, Antitumor,
pubmed-meshheading:18632190-Humans,
pubmed-meshheading:18632190-Pyrazoles,
pubmed-meshheading:18632190-Structure-Activity Relationship,
pubmed-meshheading:18632190-Triazines
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pubmed:year |
2009
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pubmed:articleTitle |
Cyclocondensation reaction of heterocyclic carbonyl compounds. Part XIII: synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines.
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pubmed:affiliation |
Department of Organic Chemistry, Faculty of Science, Palacký University, Tr. Svobody 8, 77146 Olomouc, Czech Republic. akrylhydrazid@seznam.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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