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pubmed-article:18629630pubmed:abstractTextIn our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy. The aim of this study was to evaluate SIAH2 for its (a) predictive/prognostic value, and (b) functional role in endocrine therapy resistance.lld:pubmed
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pubmed-article:18629630pubmed:articleTitleDownregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer.lld:pubmed
pubmed-article:18629630pubmed:affiliationDepartment of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, The Netherlands. m.p.h.m.jansen@erasmusmc.nllld:pubmed
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