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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-6-15
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pubmed:abstractText |
In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy. The aim of this study was to evaluate SIAH2 for its (a) predictive/prognostic value, and (b) functional role in endocrine therapy resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/seven in absentia proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1573-7217
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pubmed:author |
pubmed-author:BernsEls M J JEM,
pubmed-author:DorssersLambert C JLC,
pubmed-author:FoekensJohn AJA,
pubmed-author:HellemanJozienJ,
pubmed-author:JansenMaurice P H MMP,
pubmed-author:KlijnJan G MJG,
pubmed-author:LookMaxime PMP,
pubmed-author:Meijer-van GelderMarion EME,
pubmed-author:Ruigrok-RitstierKirstenK,
pubmed-author:SieuwertsAnieta MAM,
pubmed-author:SleijferStefanS,
pubmed-author:van StaverenIris LIL
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pubmed:issnType |
Electronic
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18629630-Adult,
pubmed-meshheading:18629630-Aged,
pubmed-meshheading:18629630-Antineoplastic Agents, Hormonal,
pubmed-meshheading:18629630-Blotting, Western,
pubmed-meshheading:18629630-Breast Neoplasms,
pubmed-meshheading:18629630-Disease-Free Survival,
pubmed-meshheading:18629630-Drug Resistance, Neoplasm,
pubmed-meshheading:18629630-Epidermal Growth Factor,
pubmed-meshheading:18629630-Estradiol,
pubmed-meshheading:18629630-Female,
pubmed-meshheading:18629630-Humans,
pubmed-meshheading:18629630-Kaplan-Meier Estimate,
pubmed-meshheading:18629630-Middle Aged,
pubmed-meshheading:18629630-Nuclear Proteins,
pubmed-meshheading:18629630-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18629630-Prognosis,
pubmed-meshheading:18629630-RNA, Messenger,
pubmed-meshheading:18629630-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18629630-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18629630-Selective Estrogen Receptor Modulators,
pubmed-meshheading:18629630-Treatment Outcome,
pubmed-meshheading:18629630-Tumor Markers, Biological,
pubmed-meshheading:18629630-Ubiquitin-Protein Ligases
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pubmed:year |
2009
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pubmed:articleTitle |
Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer.
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pubmed:affiliation |
Department of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, The Netherlands. m.p.h.m.jansen@erasmusmc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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