Source:http://linkedlifedata.com/resource/pubmed/id/18627257
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2008-7-16
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| pubmed:abstractText |
A three-dimensional (3D) finite element model (FEM) that simulates the Impactor weight-drop experimental model of traumatic spinal cord injury (SCI) was developed. The model consists of the rat spinal cord, with distinct element sets for the gray and white matter, the cerebrospinal fluid (CSF), the dura mater, a rigid rat spinal column, and a rigid impactor. Loading conditions were taken from the average impact velocities determined from previous parallel weight-drop experiments employing a 2.5-mm-diameter, 10-g rod dropped from either 12.5 or 25 mm. The mechanical properties were calibrated by comparing the predicted displacement of the spinal cord at the impact site to that measured experimentally. Parametric studies were performed to determine the sensitivity of the model to the relevant material properties, loading conditions, and essential boundary conditions, and it was determined that the shear modulus had the greatest influence on spinal cord displacement. Additional simulations were performed where gray and white matter were prescribed different material properties. These simulations generated similar drop trajectories to the homogeneous model, but the stress and strain distributions better matched patterns of acute albumin extravasation across the blood-spinal cord barrier following weight-drop SCI, as judged by a logit analysis. A final simulation was performed where the impact site was shifted laterally by 0.35 mm. The off-center impact had little effect on the rod trajectory, but caused marked shifts in the location of stress and strain contours. Different combinations of parameter values could reproduce the impactor trajectory, which suggests that another experimental measure of the tissue response is required for validation. The FEM can be a valuable tool for understanding the injury biomechanics associated with experimental SCI to identify areas for improvement in animal models and future research to identify thresholds for injury.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0897-7151
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
795-816
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| pubmed:meshHeading |
pubmed-meshheading:18627257-Animals,
pubmed-meshheading:18627257-Biomechanics,
pubmed-meshheading:18627257-Blood-Brain Barrier,
pubmed-meshheading:18627257-Computer Simulation,
pubmed-meshheading:18627257-Disease Models, Animal,
pubmed-meshheading:18627257-Female,
pubmed-meshheading:18627257-Finite Element Analysis,
pubmed-meshheading:18627257-Image Processing, Computer-Assisted,
pubmed-meshheading:18627257-Magnetic Resonance Imaging,
pubmed-meshheading:18627257-Nerve Fibers, Myelinated,
pubmed-meshheading:18627257-Rats,
pubmed-meshheading:18627257-Rats, Long-Evans,
pubmed-meshheading:18627257-Reproducibility of Results,
pubmed-meshheading:18627257-Spinal Cord,
pubmed-meshheading:18627257-Spinal Cord Injuries,
pubmed-meshheading:18627257-Stress, Mechanical,
pubmed-meshheading:18627257-Wounds, Nonpenetrating
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| pubmed:year |
2008
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| pubmed:articleTitle |
Finite element analysis of spinal cord injury in the rat.
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| pubmed:affiliation |
Department of Biomedical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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