Source:http://linkedlifedata.com/resource/pubmed/id/18617334
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2008-11-5
|
| pubmed:abstractText |
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0344-0338
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
204
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
793-7
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| pubmed:meshHeading |
pubmed-meshheading:18617334-Carcinoma, Squamous Cell,
pubmed-meshheading:18617334-Genes, APC,
pubmed-meshheading:18617334-Humans,
pubmed-meshheading:18617334-Loss of Heterozygosity,
pubmed-meshheading:18617334-Mouth Neoplasms,
pubmed-meshheading:18617334-Polymerase Chain Reaction,
pubmed-meshheading:18617334-Polymorphism, Restriction Fragment Length
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Loss of heterozygosity of the APC gene in oral squamous cell carcinoma.
|
| pubmed:affiliation |
Department of Pathology, Health Science Center, Federal University of Santa Catarina, CEP 88040-370, Florianópolis, SC, Brazil. riet@ccs.ufsc.br
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|