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pubmed-article:18601967pubmed:abstractTextTransgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.lld:pubmed
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pubmed-article:18601967pubmed:articleTitleImmunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.lld:pubmed
pubmed-article:18601967pubmed:affiliationDepartment of Virology, Unité de Rétrovirologie Moléculaire, CNRS URA 3015, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France.lld:pubmed
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