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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
35
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|
pubmed:dateCreated |
2008-8-6
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|
pubmed:abstractText |
Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0264-410X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
18
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4477-85
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|
pubmed:meshHeading |
pubmed-meshheading:18601967-AIDS Vaccines,
pubmed-meshheading:18601967-Administration, Oral,
pubmed-meshheading:18601967-Animals,
pubmed-meshheading:18601967-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18601967-Epitopes,
pubmed-meshheading:18601967-Female,
pubmed-meshheading:18601967-Flow Cytometry,
pubmed-meshheading:18601967-HIV-1,
pubmed-meshheading:18601967-Hepatitis B Vaccines,
pubmed-meshheading:18601967-Hepatitis B virus,
pubmed-meshheading:18601967-Immunization, Secondary,
pubmed-meshheading:18601967-Lymph Nodes,
pubmed-meshheading:18601967-Lymphocyte Activation,
pubmed-meshheading:18601967-Lymphocyte Subsets,
pubmed-meshheading:18601967-Mice,
pubmed-meshheading:18601967-Plants, Genetically Modified,
pubmed-meshheading:18601967-T-Lymphocytes, Regulatory,
pubmed-meshheading:18601967-Tobacco,
pubmed-meshheading:18601967-Vaccines, DNA,
pubmed-meshheading:18601967-Vaccines, Edible,
pubmed-meshheading:18601967-Vaccines, Virosome,
pubmed-meshheading:18601967-Viral Proteins
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.
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|
pubmed:affiliation |
Department of Virology, Unité de Rétrovirologie Moléculaire, CNRS URA 3015, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
