Source:http://linkedlifedata.com/resource/pubmed/id/18598019
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
15
|
pubmed:dateCreated |
2008-8-8
|
pubmed:abstractText |
Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in vitro. Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1520-4804
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:day |
14
|
pubmed:volume |
51
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4834-8
|
pubmed:meshHeading |
pubmed-meshheading:18598019-Animals,
pubmed-meshheading:18598019-Antineoplastic Agents,
pubmed-meshheading:18598019-Apoptosis,
pubmed-meshheading:18598019-Carcinoma, Hepatocellular,
pubmed-meshheading:18598019-Cell Line,
pubmed-meshheading:18598019-Drug Design,
pubmed-meshheading:18598019-Humans,
pubmed-meshheading:18598019-Liver Neoplasms,
pubmed-meshheading:18598019-Male,
pubmed-meshheading:18598019-Mice,
pubmed-meshheading:18598019-Mice, Inbred BALB C,
pubmed-meshheading:18598019-Molecular Structure,
pubmed-meshheading:18598019-Nitric Oxide,
pubmed-meshheading:18598019-Oleanolic Acid
|
pubmed:year |
2008
|
pubmed:articleTitle |
Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.
|
pubmed:affiliation |
Department of Phytochemistry, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|