Linked Life Data

18595787

Source:http://linkedlifedata.com/resource/pubmed/id/18595787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-10-22
pubmed:abstractText
The fabrication of three-dimensional (3-D) structures using computer-controlled ultraviolet (UV) photopolymerization of acrylates (laser stereolithography) often results in the trapping of residual unreacted monomer and initiator. These residuals can leach from the finished structure and affect the biological response of cells and tissues. Thus the potential applications of these structures for tissue engineering have not been fully realized. In this paper we demonstrate that conventional post-lithography treatments followed by processing in the environmentally benign solvent, supercritical carbon dioxide (scCO(2)), dramatically increased biocompatibility. The scCO(2) processing of pure polyacrylate and polyacrylate/hydroxyapatite composite structures extracts residuals from all structures including those that had received full conventional post-lithography treatment (acetone washing/UV drying). Human osteoblast cells seeded on the extracted surfaces of these structures demonstrated increased cell attachment and proliferation on the scCO(2)-treated materials.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1878-7568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1603-10
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction.
pubmed:affiliation
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't