Source:http://linkedlifedata.com/resource/pubmed/id/18595202
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-7-2
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| pubmed:abstractText |
Serum surfactant protein (SP)-A offers a useful clinical marker for interstitial lung disease (ILD). However, SP-A is occasionally elevated in non-ILD pulmonary patients. The present study was conducted to investigate factors that affect serum SP- A levels in respiratory medicine. Serum SP-A, serum SP-D, serum Klebs von den Lungen (KL)-6 and pulmonary function tests were evaluated in 929 patients (current smokers, n=255; ex-smokers, n=242; never-smokers, n=432) without ILD or pulmonary alveolar proteinosis. Serum SP-A was significantly higher in current smokers than in never- or ex-smokers (p<0.01 and p<0.05, respectively). Serum SP- A was significantly higher in chronic obstructive pulmonary disease (COPD) and pulmonary thromboembolism than in other diseases (p<0.01). Serum SP-A correlated positively with amount of smoking (p<0.01) and negatively with forced expiratory volume in 1 s/forced vital capacity (p<0.05). Serum SP-D and KL-6 were unaffected by smoking. Smoking should be taken into account when evaluating serum SP-A levels, and different baseline levels of serum SP-A should be established for smokers and non-smokers. Serum SP-A may also represent a useful marker for predicting COPD in the preclinical stage.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/MUC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactant-Associated...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1354-750X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
385-92
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:18595202-Adult,
pubmed-meshheading:18595202-Aged,
pubmed-meshheading:18595202-Aged, 80 and over,
pubmed-meshheading:18595202-Biological Markers,
pubmed-meshheading:18595202-Female,
pubmed-meshheading:18595202-Forced Expiratory Volume,
pubmed-meshheading:18595202-Humans,
pubmed-meshheading:18595202-Lung,
pubmed-meshheading:18595202-Lung Diseases,
pubmed-meshheading:18595202-Male,
pubmed-meshheading:18595202-Middle Aged,
pubmed-meshheading:18595202-Mucin-1,
pubmed-meshheading:18595202-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:18595202-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:18595202-Pulmonary Surfactant-Associated Protein D,
pubmed-meshheading:18595202-Respiratory Function Tests,
pubmed-meshheading:18595202-Smoking,
pubmed-meshheading:18595202-Smoking Cessation
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| pubmed:year |
2008
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| pubmed:articleTitle |
Serum surfactant protein-A, but not surfactant protein-D or KL-6, can predict preclinical lung damage induced by smoking.
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| pubmed:affiliation |
Division of Pulmonary Medicine, Department of Medicine, National Defense Medical College, Tokorozawa, Japan. kobahide@ndmc.ac.jp
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| pubmed:publicationType |
Journal Article
|