Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-10-8
pubmed:abstractText
To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients. We found that a platelet count at diagnosis greater than 1000 x 10(9)/L was associated with significantly lower rate of thrombosis in multivariable analysis and, if combined with leukocytes less than 11 x 10(9)/L, pointed to a "low-risk" category with a rate of thrombosis of 1.59% of patients/year. On the contrary, the highest risk category (thrombosis rate, 2.95% of patients/year) was constituted of patients with leukocytosis, lower platelet count, and a JAK2(V617F) mutated genotype in most cases (77% vs 26% in the low-risk group), independently from standard risk factors. These data challenge the theory that elevated platelet count increases thrombosis risk in ET and suggest prospective clinical trials to support this hypothesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-15003898, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-15667529, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-16000354, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-16000360, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-16029444, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-16622614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-16988161, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-17110452, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-17156406, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-17625606, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-18024652, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-18669880, http://linkedlifedata.com/resource/pubmed/commentcorrection/18587010-18840727
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3135-7
pubmed:dateRevised
2010-9-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia.
pubmed:affiliation
Department of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't