18586887

Source:http://linkedlifedata.com/resource/pubmed/id/18586887

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015127, umls-concept:C0034144, umls-concept:C0042510, umls-concept:C0220806, umls-concept:C0547070, umls-concept:C1280551, umls-concept:C1314792, umls-concept:C1521828, umls-concept:C1549081, umls-concept:C1692758, umls-concept:C1879547
pubmed:issue	2
pubmed:dateCreated	2008-8-8
pubmed:abstractText	Endocardial mapping has suggested that Purkinje fibers may play a role in the maintenance of long-duration ventricular fibrillation (LDVF). To determine the influence of Purkinje fibers on LDVF, we chemically ablated the Purkinje system with Lugol solution and recorded endocardial and transmural activation during LDVF. Dog hearts were isolated and perfused, and the ventricular endocardium was exposed and treated with Lugol solution (n = 6) or normal Tyrode solution as a control (n = 6). The left anterior papillary muscle endocardium was mapped with a 504-electrode (21 x 24) plaque with electrodes spaced 1 mm apart. Transmural activation was recorded with a six-electrode plunge needle on each side of the plaque. Ventricular fibrillation (VF) was induced, and perfusion was halted. LDVF spontaneously terminated sooner in Lugol-ablated hearts than in control hearts (4.9 +/- 1.5 vs. 9.2 +/- 3.2 min, P = 0.01). After termination of VF, both the control and Lugol hearts were typically excitable, but only short episodes of VF could be reinduced. Endocardial activation rates were similar during the first 2 min of LDVF for Lugol-ablated and control hearts but were significantly slower in Lugol hearts by 3 min. In control hearts, the endocardium activated more rapidly than the epicardium after 4 min of LDVF with wave fronts propagating most often from the endocardium to epicardium. No difference in transmural activation rate or wave front direction was observed in Lugol hearts. Ablation of the subendocardium hastens VF spontaneous termination and alters VF activation sequences, suggesting that Purkinje fibers are important in the maintenance of LDVF.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/HL-28429, http://linkedlifedata.com/resource/pubmed/grant/HL-64184, http://linkedlifedata.com/resource/pubmed/grant/HL-85370, http://linkedlifedata.com/resource/pubmed/grant/T32 HL-07457-16
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100901228
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Iodides, http://linkedlifedata.com/resource/pubmed/chemical/Lugol's solution
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0363-6135
pubmed:author	pubmed-author:DosdallDerek JDJ, pubmed-author:HuangJianJ, pubmed-author:IdekerRaymond ERE, pubmed-author:KillingsworthCheryl RCR, pubmed-author:KimJong JJJ, pubmed-author:RobertsonPeter GPG, pubmed-author:RogersJack MJM, pubmed-author:SmithWilliam MWM, pubmed-author:TabereauxPaul BPB, pubmed-author:WalcottGregory PGP
pubmed:issnType	Print
pubmed:volume	295
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	H883-9
pubmed:dateRevised	2010-9-22
pubmed:meshHeading	pubmed-meshheading:18586887-Action Potentials, pubmed-meshheading:18586887-Animals, pubmed-meshheading:18586887-Body Surface Potential Mapping, pubmed-meshheading:18586887-Cardiac Pacing, Artificial, pubmed-meshheading:18586887-Disease Models, Animal, pubmed-meshheading:18586887-Dogs, pubmed-meshheading:18586887-Endocardium, pubmed-meshheading:18586887-Iodides, pubmed-meshheading:18586887-Purkinje Fibers, pubmed-meshheading:18586887-Time Factors, pubmed-meshheading:18586887-Ventricular Fibrillation
pubmed:year	2008
pubmed:articleTitle	Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs.
pubmed:affiliation	Volker Hall B140, 1670 Univ. Blvd., Birmingham, AL 35294-0019, USA.
pubmed:publicationType	Journal Article, In Vitro

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