| pubmed-article:18585064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:18585064 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:18585064 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18585064 | pubmed:dateCreated | 2008-7-17 | lld:pubmed |
| pubmed-article:18585064 | pubmed:abstractText | gammadelta T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific gammadelta T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-gammadelta T cells produced IL-17, whereas ligand-experienced cells made IFN-gamma. Immediately after immunization, a large fraction of IL-17(+) gammadelta T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17(+) *beta T cells. Thus, thymic selection determines the effector fate of gammadelta T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens. | lld:pubmed |
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| pubmed-article:18585064 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18585064 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18585064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18585064 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18585064 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:DavisMark MMM | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:SteinmanLawre... | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:YamasakiShoS | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:SaitoTakashiT | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:YoussefSawsan... | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:BaumgarthNico... | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:LocksleyRicha... | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:ChienYueh-hsi... | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:ShinSunnyS | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:SuXiaoqinX | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:LiLukeL | lld:pubmed |
| pubmed-article:18585064 | pubmed:author | pubmed-author:JensenKirk... | lld:pubmed |
| pubmed-article:18585064 | pubmed:issnType | Electronic | lld:pubmed |
