Linked Life Data

18573354

Source:http://linkedlifedata.com/resource/pubmed/id/18573354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-11-18
pubmed:abstractText
The relationship between infections and antiphospholipid antibodies or antiphospholipid syndrome is an intriguing question. A two and a half year old child with trisomy 21, who suffered three severe episodes of thrombosis each taking place after an infection, is described here. As high titres of IgG anticardiolipin (ACL) antibodies was registered during the second and third episodes, the antiphospholipid syndrome was suspected. IgM as well as IgG and IgA ACL antibodies have been described at different titres in a wide variety of infections, although they are not usually associated with thrombosis. In this particular case the timing of events and their association with high IgG ACL antibody titres seemed to implicate infection in the pathogenesis of the antiphospholipid syndrome. It can be hypothesized that some infections not only "trigger" antiphospholipid antibody production, but--in genetically predisposed subjects--can induce the clinical manifestations of the antiphospholipid syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-0183
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-3
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The antiphospholipid syndrome and infections in a child with trisomy 21.
pubmed:affiliation
Rheumatology Unit, University of Padua, Padua, Italy. arielahoxha@hotmail.com
pubmed:publicationType
Journal Article, Case Reports