Source:http://linkedlifedata.com/resource/pubmed/id/18573294
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
50
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| pubmed:dateCreated |
2008-11-17
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| pubmed:abstractText |
This study, done during the 2002--2003 season among children <6 years of age to investigate influenza vaccine effectiveness and confounding factors, involved 2913 children (1512 vaccinees, 1401 non-vaccinees) recruited from 54 paediatric clinics. Between December 2002 and April 2003, parents reported their children's maximum body temperatures weekly. Influenza-like illness (ILI) was defined as an acute febrile illness (> or =38.0 degrees C) during the peak epidemic period. Adjusted odds ratios (ORs) for ILI were obtained using a logistic regression model. In analysis for total subjects, the ORs were significantly decreased for vaccinees (OR: 0.76, 95% CI: 0.66-0.88) and significantly increased for younger age groups, including children aged 2.0-3.9 years (1.42, 1.18-1.72) and those < 2.0 years (2.02,1.61-2.54), compared to those between 4.0 and 5.9 years. ORs were significantly increased for children who visited a physician within the last 6 months for a cold (1.27, 1.08-1.50), attended preschool (1.72, 1.45-2.04), and had > or =3 siblings (1.42, 1.15-1.74). These confounding factors are suggested to be considered in estimating vaccine effectiveness among young children. In subgroup analysis by age groups, significantly decreased ORs were seen in 2.0-3.9-year-old (0.59, 0.47-0.74) and 4.0-5.9-year-old (0.75, 0.58-0.98) vaccinees; no significant vaccine effectiveness was detected for those < 2.0 years (1.07, 0.80-1.44). Thus, among very young children vaccine effectiveness could not be demonstrated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0264-410X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
25
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| pubmed:volume |
26
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6481-5
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| pubmed:meshHeading |
pubmed-meshheading:18573294-Age Factors,
pubmed-meshheading:18573294-Child,
pubmed-meshheading:18573294-Child, Preschool,
pubmed-meshheading:18573294-Confounding Factors (Epidemiology),
pubmed-meshheading:18573294-Disease Outbreaks,
pubmed-meshheading:18573294-Female,
pubmed-meshheading:18573294-Humans,
pubmed-meshheading:18573294-Infant,
pubmed-meshheading:18573294-Influenza, Human,
pubmed-meshheading:18573294-Influenza Vaccines,
pubmed-meshheading:18573294-Japan,
pubmed-meshheading:18573294-Male,
pubmed-meshheading:18573294-Risk Factors,
pubmed-meshheading:18573294-Treatment Outcome,
pubmed-meshheading:18573294-Vaccination
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| pubmed:year |
2008
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| pubmed:articleTitle |
Influenza vaccine effectiveness and confounding factors among young children.
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| pubmed:affiliation |
Department of Public Health, Osaka City University Faculty of Medicine, Asahi-machi 1-4-3, Osaka 545-8585, Japan.
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| pubmed:publicationType |
Journal Article
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