Source:http://linkedlifedata.com/resource/pubmed/id/18572329
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2008-9-24
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| pubmed:abstractText |
Most primary ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as conjunctival mass. A 58-year-old man presented with a palpable mass in the left lower tarsal conjunctiva incidentally detected one month previously. Histopathologic examination showed proliferation of monomorphous small-to-medium sized lymphoid cells. On immunohistochemistry, tumor cells were positive for CD20, bcl-2, and cyclin D1, and negative for CD5. PCR analysis for immunoglobulin heavy chain gene rearrangement showed monoclonal B-cell proliferation. t(11;14)(q13;q32), involving the CCND1 and IGH genes, was detected in interphase fluorescent in situ hybridization using formalin-fixed, paraffin-embedded tissue; however, MALT1 gene translocation was not observed. The final diagnosis was mantle cell lymphoma. There was no lymphadenopathy; however, bone marrow involvement of the lymphoma was suspected. The patient has been receiving systemic chemotherapy. This case emphasizes the differential diagnosis of conjunctival mantle cell lymphoma from extranodal marginal zone B-cell lymphomas of MALT regarding the clinical and pathological aspects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0344-0338
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
204
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
779-83
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| pubmed:meshHeading |
pubmed-meshheading:18572329-Antigens, CD5,
pubmed-meshheading:18572329-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18572329-Cell Proliferation,
pubmed-meshheading:18572329-Conjunctival Neoplasms,
pubmed-meshheading:18572329-Cyclin D1,
pubmed-meshheading:18572329-Diagnosis, Differential,
pubmed-meshheading:18572329-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18572329-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:18572329-Humans,
pubmed-meshheading:18572329-Immunoglobulin Heavy Chains,
pubmed-meshheading:18572329-Immunohistochemistry,
pubmed-meshheading:18572329-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18572329-Incidental Findings,
pubmed-meshheading:18572329-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:18572329-Lymphoma, Mantle-Cell,
pubmed-meshheading:18572329-Male,
pubmed-meshheading:18572329-Middle Aged,
pubmed-meshheading:18572329-Translocation, Genetic
|
| pubmed:year |
2008
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| pubmed:articleTitle |
CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case report.
|
| pubmed:affiliation |
Department of Pathology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongro-gu, Seoul 110-799, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Case Reports
|