|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2008-7-28
|
|
pubmed:abstractText |
Helper-dependent adenoviral vectors (HDAd) can mediate long-term phenotypic correction in the ornithine transacarbamylase (OTC)-deficient mice model with negligible chronic toxicity. However, the high doses required for metabolic correction will result in systemic inflammatory response syndrome in humans. This acute toxicity represents the major obstacle for clinical applications of HDAd vectors for the treatment of OTC deficiency. Strategies for reducing the dose necessary for disease correction are highly desirable because HDAd acute toxicity is clearly dose-dependent.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-10064660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-10759467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-11148551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-11356076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-11779420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-11987790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-12490001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-1281456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-14512318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-14567964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-14599819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-14965376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-15336649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-15451463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-15466081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-15963925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-16000063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-16154372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-16677864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-16871229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-17285138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-17538087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-17979676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-6717540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-8631974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563850-9686349
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1521-2254
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
(c) 2008 John Wiley & Sons, Ltd.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
890-6
|
|
pubmed:dateRevised |
2011-8-1
|
|
pubmed:meshHeading |
pubmed-meshheading:18563850-Adenoviridae,
pubmed-meshheading:18563850-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:18563850-Animals,
pubmed-meshheading:18563850-Disease Models, Animal,
pubmed-meshheading:18563850-Gene Therapy,
pubmed-meshheading:18563850-Genetic Vectors,
pubmed-meshheading:18563850-Helper Viruses,
pubmed-meshheading:18563850-Histocytochemistry,
pubmed-meshheading:18563850-Liver,
pubmed-meshheading:18563850-Mice,
pubmed-meshheading:18563850-Mice, Mutant Strains,
pubmed-meshheading:18563850-Ornithine Carbamoyltransferase,
pubmed-meshheading:18563850-Ornithine Carbamoyltransferase Deficiency Disease,
pubmed-meshheading:18563850-Orotic Acid,
pubmed-meshheading:18563850-Transgenes
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors.
|
|
pubmed:affiliation |
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
