| pubmed-article:18562479 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0005682 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0011696 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0441722 | lld:lifeskim |
| pubmed-article:18562479 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:18562479 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18562479 | pubmed:dateCreated | 2008-8-7 | lld:pubmed |
| pubmed-article:18562479 | pubmed:abstractText | Role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin-deficient mice (Des(-/-)). A partial obstruction of the urethra was created, and after 9-19 days bladder weight increased approximately threefold in both Des(-/-) and wild type (Des(+/+)) animals. Bladder growth was associated with the synthesis of actin and myosin. In the hypertrophic Des(+/+) bladder, the relative content of desmin increased. In Des(-/-)mice, desmin was absent. No alterations in the amount of vimentin were observed. Although Des(-/-) obstructed bladders were capable of growth, they had structural changes with a partial disruption of the wall. Des(-/-)bladders had slightly lower passive stress and significantly lower active stress compared with Des(+/+). Des(-/-)preparations had lower shortening velocity. During hypertrophy, these structural and mechanical alterations in the Des(-/-)urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. | lld:pubmed |
| pubmed-article:18562479 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18562479 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562479 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18562479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562479 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18562479 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18562479 | pubmed:issn | 0363-6143 | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:PaulinDD | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:SmallJ VJV | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:MASS | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:ArnerAA | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:UveliusBB | lld:pubmed |
| pubmed-article:18562479 | pubmed:author | pubmed-author:ScottR... | lld:pubmed |
| pubmed-article:18562479 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18562479 | pubmed:volume | 295 | lld:pubmed |
| pubmed-article:18562479 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18562479 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18562479 | pubmed:pagination | C324-31 | lld:pubmed |
| pubmed-article:18562479 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18562479 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18562479 | pubmed:articleTitle | Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder. | lld:pubmed |
| pubmed-article:18562479 | pubmed:affiliation | Dept. of Physiology and Pharmacology, Karolinska Institutet, v Eulers v 8, SE 171 77 Stockholm, Sweden. | lld:pubmed |
| pubmed-article:18562479 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18562479 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:13346 | entrezgene:pubmed | pubmed-article:18562479 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18562479 | lld:entrezgene |
