Source:http://linkedlifedata.com/resource/pubmed/id/18562479
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-8-7
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| pubmed:abstractText |
Role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin-deficient mice (Des(-/-)). A partial obstruction of the urethra was created, and after 9-19 days bladder weight increased approximately threefold in both Des(-/-) and wild type (Des(+/+)) animals. Bladder growth was associated with the synthesis of actin and myosin. In the hypertrophic Des(+/+) bladder, the relative content of desmin increased. In Des(-/-)mice, desmin was absent. No alterations in the amount of vimentin were observed. Although Des(-/-) obstructed bladders were capable of growth, they had structural changes with a partial disruption of the wall. Des(-/-)bladders had slightly lower passive stress and significantly lower active stress compared with Des(+/+). Des(-/-)preparations had lower shortening velocity. During hypertrophy, these structural and mechanical alterations in the Des(-/-)urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0363-6143
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
295
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
C324-31
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18562479-Actins,
pubmed-meshheading:18562479-Animals,
pubmed-meshheading:18562479-Biomechanics,
pubmed-meshheading:18562479-Desmin,
pubmed-meshheading:18562479-Disease Models, Animal,
pubmed-meshheading:18562479-Female,
pubmed-meshheading:18562479-Hypertrophy,
pubmed-meshheading:18562479-Intermediate Filament Proteins,
pubmed-meshheading:18562479-Mice,
pubmed-meshheading:18562479-Mice, Inbred C57BL,
pubmed-meshheading:18562479-Mice, Knockout,
pubmed-meshheading:18562479-Microscopy, Electron, Transmission,
pubmed-meshheading:18562479-Muscle, Smooth,
pubmed-meshheading:18562479-Muscle Contraction,
pubmed-meshheading:18562479-Myocardium,
pubmed-meshheading:18562479-Myosins,
pubmed-meshheading:18562479-Organ Size,
pubmed-meshheading:18562479-Urethral Obstruction,
pubmed-meshheading:18562479-Urinary Bladder
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder.
|
| pubmed:affiliation |
Dept. of Physiology and Pharmacology, Karolinska Institutet, v Eulers v 8, SE 171 77 Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|