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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-8-13
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pubmed:abstractText |
The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The International Study of Postoperative Cognitive Dysfunction recruited 1218 subjects >or= 60 years old undergoing elective, non-cardiac surgery. Postoperatively, subjects were evaluated for delirium using the criteria of the Diagnostic and Statistical Manual. Subjects underwent neuropsychological testing pre-operatively and postoperatively at 7 days (n = 1018) and 3 months (n = 946). Postoperative cognitive dysfunction was defined as a composite Z-score > 2 across tests or at least two individual test Z-scores > 2. Subjects with delirium were significantly less likely to participate in postoperative testing. Delirium was associated with an increased incidence of early postoperative cognitive dysfunction (adjusted risk ratio 1.6, 95% CI 1.1-2.1), but not long-term postoperative cognitive dysfunction (adjusted risk ratio 1.3, 95% CI 0.6-2.4). Delirium was associated with early postoperative cognitive dysfunction, but the relationship of delirium to long-term postoperative cognitive dysfunction remains unclear.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K08 GM077057-03,
http://linkedlifedata.com/resource/pubmed/grant/K24 AG000949-08,
http://linkedlifedata.com/resource/pubmed/grant/K24AG00949,
http://linkedlifedata.com/resource/pubmed/grant/KO8GM077057,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG017649-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG018772-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG020253-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG029656-05,
http://linkedlifedata.com/resource/pubmed/grant/R01AG018772-04,
http://linkedlifedata.com/resource/pubmed/grant/R01AG17649,
http://linkedlifedata.com/resource/pubmed/grant/R01AG20253,
http://linkedlifedata.com/resource/pubmed/grant/R03 AG029861-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R03AG029861,
http://linkedlifedata.com/resource/pubmed/grant/R21 AG025193-02,
http://linkedlifedata.com/resource/pubmed/grant/R21AG025193
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-10855596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-11161124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-11172175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-11207462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-11700159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-1202204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-12534838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-12865035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-1512391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-15264710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-1574984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-16428883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-16776789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-17325500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-17325517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-2240918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-4056765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-7733754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-7733765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-8264068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-8675936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-9114631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-9525362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18547292-9832001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1365-2044
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
941-7
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:18547292-Aged,
pubmed-meshheading:18547292-Cognition Disorders,
pubmed-meshheading:18547292-Delirium,
pubmed-meshheading:18547292-Female,
pubmed-meshheading:18547292-Follow-Up Studies,
pubmed-meshheading:18547292-Humans,
pubmed-meshheading:18547292-Male,
pubmed-meshheading:18547292-Middle Aged,
pubmed-meshheading:18547292-Neuropsychological Tests,
pubmed-meshheading:18547292-Postoperative Complications,
pubmed-meshheading:18547292-Postoperative Period,
pubmed-meshheading:18547292-Prognosis,
pubmed-meshheading:18547292-Risk Assessment
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pubmed:year |
2008
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pubmed:articleTitle |
Delirium is associated with early postoperative cognitive dysfunction.
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pubmed:affiliation |
VA Boston Healthcare System, Geriatric Education and Clinical Center; Brigham and Women's Hospital, Division of Aging, Harvard Medical School, Boston, MA, USA. jrudolph@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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