Linked Life Data

18534567

Source:http://linkedlifedata.com/resource/pubmed/id/18534567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-6-27
pubmed:abstractText
Attention deficit/hyperactivity disorder (ADHD) is one of the most common but poorly understood developmental disorders in childhood. Although neuropsychological studies demonstrate that children with ADHD have attentional alerting deficits, the neurobiological bases of such deficits have not been examined extensively. In this study, by using functional magnetic resonance imaging (fMRI), we explored the neural correlates of intrinsic alertness and phasic alertness deficits in ADHD by comparing twelve boys with ADHD (13.4+/-1.7 years) with 13 age-matched normal controls (13.2+/-1.2 years) in a cued target detection task. Behaviorally, compared with the controls, the ADHD group showed a higher overall error rate and a larger reaction time variability in performing the task. At the neural level, children with ADHD showed less activation than the controls in frontal (middle and superior frontal gyrus), parietal (inferior parietal lobe, precuneus) and putamen regions. These results demonstrate that children with ADHD have deficits in alerting functions and these deficits are related to the abnormal activities in frontal and parietal regions subserving top-down attention control processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
1219
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-68
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Alerting deficits in children with attention deficit/hyperactivity disorder: event-related fMRI evidence.
pubmed:affiliation
Institute of Mental Health, Peking University, Beijing 100083, China.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't