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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2008-7-3
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pubmed:abstractText |
The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I 2 and the ionic disulfide [(C 4H 6N 2S-) 2] (2+) ( 1, dication MMI disulfide) have been isolated and their X-ray crystal structures solved. Dication MMI disulfide perchlorate acts effectively both in reducing I 2 to I (-) ions and in showing antioxidant properties in inactivating the enzyme lactoperoxidase compound I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:AragoniM CarlaMC,
pubmed-author:ArcaMassimilianoM,
pubmed-author:DemartinFrancescoF,
pubmed-author:DevillanovaFrancesco AFA,
pubmed-author:FlorisGiovanniG,
pubmed-author:GarauAlessandraA,
pubmed-author:HursthouseMichael BMB,
pubmed-author:IsaiaFrancescoF,
pubmed-author:LippolisVitoV,
pubmed-author:MeddaRosariaR,
pubmed-author:OppoFabioF,
pubmed-author:PiraMarilenaM,
pubmed-author:VeraniGaetanoG
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4050-3
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pubmed:meshHeading |
pubmed-meshheading:18529045-Antithyroid Agents,
pubmed-meshheading:18529045-Catalysis,
pubmed-meshheading:18529045-Crystallography, X-Ray,
pubmed-meshheading:18529045-Disulfides,
pubmed-meshheading:18529045-Enzyme Inhibitors,
pubmed-meshheading:18529045-Iodine,
pubmed-meshheading:18529045-Ions,
pubmed-meshheading:18529045-Lactoperoxidase,
pubmed-meshheading:18529045-Methimazole,
pubmed-meshheading:18529045-Models, Molecular,
pubmed-meshheading:18529045-Molecular Structure,
pubmed-meshheading:18529045-Oxidation-Reduction,
pubmed-meshheading:18529045-Spectrophotometry,
pubmed-meshheading:18529045-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Interaction of methimazole with I2: X-ray crystal structure of the charge transfer complex methimazole-I2. implications for the mechanism of action of methimazole-based antithyroid drugs.
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pubmed:affiliation |
Dipartimento di Chimica Inorganica ed Analitica, Università degli Studi di Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy. isaia@unica.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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