Linked Life Data

18518250

Source:http://linkedlifedata.com/resource/pubmed/id/18518250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2008-6-3
pubmed:abstractText
A model for coinfection in multiple strain infectious diseases is developed to incorporate coinfection statuses, immune and infection history, and cross immunity. It is solved for the symmetric interior equilibrium through the use of a ladder operator formalism inspired by quantum mechanical methods. We find that coinfection can fundamentally affects transmission dynamics with important epidemiologic and evolutionary consequences. It can significantly shift the distribution of age at infection for highly antigenically diverse pathogens so that in small host populations, an evolutionary strategy maximizing individual strain transmissibility might be less optimal than one which maximizes the total prevalence of all strains in the system. Alternatively, mechanisms which inhibit coinfection and thus increase total infection prevalence may be evolutionarily advantageous.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0031-9007
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
168102
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interactions of multiple strain pathogen diseases in the presence of coinfection, cross immunity, and arbitrary strain diversity.
pubmed:affiliation
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. laith@scharp.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't