Linked Life Data

1851470

Source:http://linkedlifedata.com/resource/pubmed/id/1851470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-19
pubmed:abstractText
Plates of presumptive occipital neocortex obtained from fetal rats at 14-16 days gestation were grafted into the cerebral hemisphere of newborn rats. The transplants were placed heterotopically into sensorimotor cortical lesion cavities made immediately prior to grafting. At maturity, some of the transplants were injected with the retrograde fluorescent tracers Fast Blue and Diamidino yellow. In other animals, single-unit activity in the transplants or in normal cortex was recorded using standard electrophysiological techniques. Histologically, host projections to the transplants were demonstrated by the presence of retrogradely labeled neurons in the host primary and secondary somatosensory cortices as well as several thalamic areas including the anteroventral, anteromedial, ventrobasal, mediodorsal and central medial nuclei. Additional labeling was found in the claustrum, lateral hypothalamus, zona incerta and basal forebrain. Electrophysiologically, transplant single-unit activity was evoked in 43/69 (62%) neurons by thalamic stimulation, but only 1/69 transplant neurons responded to electrical stimulation of the contralateral forepaw. In further work, volumetric measurements showed that the transplants did not ameliorate the thalamic atrophy found after neocortical lesions. These results are compared to previous studies involving the homotopic placement of sensorimotor cortical grafts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Heterotopic neocortical transplants. An anatomical and electrophysiological analysis of host projections to occipital cortical grafts placed into sensorimotor cortical lesions made in newborn rats.
pubmed:affiliation
Department of Cell Biology, Loyola University Stritch School of Medicine, Maywood, IL 60153.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't