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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5007
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pubmed:dateCreated |
1991-6-11
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pubmed:abstractText |
A mutated form of the platelet-derived growth factor (PDGF) beta receptor lacking most of its cytoplasmic domain was tested for its ability to block wild-type PDGF receptor function. PDGF induced the formation of complexes consisting of wild-type and truncated receptors. Such complexes were defective in autophosphorylation. When truncated receptors were expressed in excess compared to wild-type receptors, stimulation by PDGF of receptor autophosphorylation, association of phosphatidylinositol-3 kinase with the receptor, and calcium mobilization were blocked. Thus, a truncated receptor can inactivate wild-type receptor function by forming ligand-dependent receptor complexes (probably heterodimers) that are incapable of mediating the early steps of signal transduction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
252
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
844-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1851331-Animals,
pubmed-meshheading:1851331-Cells, Cultured,
pubmed-meshheading:1851331-Centrifugation, Density Gradient,
pubmed-meshheading:1851331-Cricetinae,
pubmed-meshheading:1851331-Ligands,
pubmed-meshheading:1851331-Mice,
pubmed-meshheading:1851331-Mice, Inbred BALB C,
pubmed-meshheading:1851331-Phosphorylation,
pubmed-meshheading:1851331-Platelet-Derived Growth Factor,
pubmed-meshheading:1851331-Receptors, Cell Surface,
pubmed-meshheading:1851331-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:1851331-Signal Transduction
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pubmed:year |
1991
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pubmed:articleTitle |
Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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