Linked Life Data

18512344

Source:http://linkedlifedata.com/resource/pubmed/id/18512344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-6-2
pubmed:abstractText
Cryptosporidium exhibits a complex strategy to invade and establish productive infection sites, involving complimentary parasite and host cell processes. While the work regarding host cell actin remodeling has greatly enhanced our understanding of the molecular pathways involved in the parasite induced actin reorganization, the specific function of host cell actin remodeling is still equivocal. We contend that host cell actin polymerization contributes to the development of productive C. parvum infection sites by generating membrane protrusion events, which may assist in the retention of the parasite at the apical surface within the unique extracytoplasmic niche. With our current understanding of the molecular pathways initiating actin remodeling upon C. parvum interactions with host cells, the next logical step is to determine the upstream events resulting in PI3K activation and the specific role of actin remodeling in parasite development, a process that may have implications beyond host-pathogen interactions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-0225
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
92-100
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Host cell actin remodeling in response to Cryptosporidium.
pubmed:affiliation
Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, 200 First Street, SW, Rochester, Minnesota 55905, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural