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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-9-12
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pubmed:abstractText |
Polysaccharides such as chondroitin play a potent role in tumor growth, tissue repair and angiogenesis. These properties make chondroitin a good candidate for novel drug delivery systems. Diammine dicarboxylic acid platinum (DDAP), a novel polymeric platinum compound, was developed by conjugating the platinum analogue to aspartate-chondroitin for drug delivery to tumor cells. DDAP improves platinum solubility which may reduce systemic toxicity and be more efficacious than cisplatin in killing tumor cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2272-82
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pubmed:meshHeading |
pubmed-meshheading:18509599-Antineoplastic Agents,
pubmed-meshheading:18509599-Apoptosis,
pubmed-meshheading:18509599-Aspartic Acid,
pubmed-meshheading:18509599-Cell Proliferation,
pubmed-meshheading:18509599-Chondroitin,
pubmed-meshheading:18509599-Cisplatin,
pubmed-meshheading:18509599-Cyclin A,
pubmed-meshheading:18509599-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:18509599-Dose-Response Relationship, Drug,
pubmed-meshheading:18509599-Drug Resistance, Neoplasm,
pubmed-meshheading:18509599-Female,
pubmed-meshheading:18509599-Humans,
pubmed-meshheading:18509599-Organoplatinum Compounds,
pubmed-meshheading:18509599-Ovarian Neoplasms,
pubmed-meshheading:18509599-S Phase
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pubmed:year |
2008
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pubmed:articleTitle |
Diammine dicarboxylic acid platinum enhances cytotoxicity in platinum-resistant ovarian cancer cells through induction of apoptosis and S-phase cell arrest.
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pubmed:affiliation |
Department of Gynecologic Oncology, Unit 1362, The University of Texas M. D. Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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