Linked Life Data

18501516

Source:http://linkedlifedata.com/resource/pubmed/id/18501516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-6-9
pubmed:abstractText
The aim of the present work was to perform, by in situ hybridization, a time-course analysis of the glial cell line-derived neurotrophic factor (GDNF) and its receptor mRNA expression in two models of brain injury in the rat: (a) excitotoxic lesion by ibotenic acid injection in the hippocampal formation; (b) mechanical lesion by needle insertion through the cerebral cortex including the white matter of the corpus callosum. The time-course analysis, ranging from 6h to 8 days, showed that the GDNF and its receptor (RET, GFRalpha-1 and GFRalpha-2) mRNA expressions were differentially up-regulated in both models of lesion. This in vivo regulation of the GDNF and its receptor mRNA expression indicates their involvement in the process of neuronal protection and regeneration occurring after brain injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
439
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Time-course of GDNF and its receptor expression after brain injury in the rat.
pubmed:affiliation
University of Palermo, Department of Experimental Medicine, Division of Human Physiology, corso Tukory 129, 1-90134 Palermo, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't