Linked Life Data

18496207

Source:http://linkedlifedata.com/resource/pubmed/id/18496207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-5-22
pubmed:abstractText
The cell adhesion proteins protocadherins and cadherins, through their effects on guiding neurons during development, neuronal differentiation, and synaptogenesis, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Thus, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7-kb deletion affecting PCDH-alpha exons 8-10 (alpha 8-alpha 10 Delta), was analyzed in this study as a potential candidate variant in SZ and BD.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1473-5873
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA. Lachman@aecom.yu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural