18493075

Source:http://linkedlifedata.com/resource/pubmed/id/18493075

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015219, umls-concept:C0205154
pubmed:issue	1
pubmed:dateCreated	2008-5-21
pubmed:abstractText	In a recent article, Desai and Fisher proposed that the speed of adaptation in an asexual population is determined by the dynamics of the stochastic edge of the population, that is, by the emergence and subsequent establishment of rare mutants that exceed the fitness of all sequences currently present in the population. Desai and Fisher perform an elaborate stochastic calculation of the mean time tau until a new class of mutants has been established and interpret 1/tau as the speed of adaptation. As they note, however, their calculations are valid only for moderate speeds. This limitation arises from their method to determine tau: Desai and Fisher back extrapolate the value of tau from the best-fit class's exponential growth at infinite time. This approach is not valid when the population adapts rapidly, because in this case the best-fit class grows nonexponentially during the relevant time interval. Here, we substantially extend Desai and Fisher's analysis of the stochastic edge. We show that we can apply Desai and Fisher's method to high speeds by either exponentially back extrapolating from finite time or using a nonexponential back extrapolation. Our results are compatible with predictions made using a different analytical approach (Rouzine et al.) and agree well with numerical simulations.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 AI0639236, http://linkedlifedata.com/resource/pubmed/grant/R01 AI065960
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-10835413, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-11238990, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-12525686, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-15342539, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-17331728, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-17483432, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-17984061, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-17997597, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-18023832, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-5548029, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-7498757, http://linkedlifedata.com/resource/pubmed/commentcorrection/18493075-9093555
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374636
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0016-6731
pubmed:author	pubmed-author:BrunetEricE, pubmed-author:RouzineIgor MIM, pubmed-author:WilkeClaus OCO
pubmed:issnType	Print
pubmed:volume	179
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	603-20
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:18493075-Adaptation, Biological, pubmed-meshheading:18493075-Biological Evolution, pubmed-meshheading:18493075-Computer Simulation, pubmed-meshheading:18493075-Genetics, Population, pubmed-meshheading:18493075-Models, Genetic, pubmed-meshheading:18493075-Stochastic Processes
pubmed:year	2008
pubmed:articleTitle	The stochastic edge in adaptive evolution.
pubmed:affiliation	Laboratoire de Physique Statistique, Ecole Normale Supérieure, 75230 Paris Cedex 05, France.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural