Linked Life Data

18487018

Source:http://linkedlifedata.com/resource/pubmed/id/18487018

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-6-18
pubmed:abstractText
There is evidence suggesting that inflammation plays an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important pro-inflammatory cytokine, and some authors have demonstrated that IL-6 promoter polymorphism -572G>C is associated with IAs in Caucasian population. We performed a case-control study to investigate whether this single nucleotide polymorphism (SNP) might affect the development of IAs in Chinese Han population. The study groups comprised 240 Chinese Han nationality aneurysmal patients and 240 controls. Differences in genotype and allele frequencies between patients and controls were tested by the chi-square method. The results showed that among the Chinese Han subjects, there were significant differences in genotypic distribution and allele frequencies between aneurysmal patients and controls. The GG genotype was significantly more common in patients than in controls (24.5% vs. 3.7%, p<0.001, odds ratio 8.366, 95% CI: 4.040-17.324), and the G allele was much more frequent in patients than in controls (51.7% vs. 20.8%, p<0.001, odds ratio 4.062, 95% CI: 3.058-5.395).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
440
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The interleukin-6 gene -572G>C promoter polymorphism is related to intracranial aneurysms in Chinese Han nationality.
pubmed:affiliation
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
pubmed:publicationType
Journal Article