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pubmed-article:1848685pubmed:abstractTextAutoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.lld:pubmed
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pubmed-article:1848685pubmed:articleTitleClonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.lld:pubmed
pubmed-article:1848685pubmed:affiliationLudwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.lld:pubmed
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