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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-5-12
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pubmed:databankReference |
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pubmed:abstractText |
The SMART study randomized 5,472 human immunodeficiency virus (HIV)-infected patients with CD4+ cell counts >350 cells/microL to intermittent antiretroviral therapy (ART; the drug conservation [DC] group) versus continuous ART (the viral suppression [VS] group). In the DC group, participants started ART when the CD4+ cell count was <250 cells/microL. Clinical outcomes in participants not receiving ART at entry inform the early use of ART.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:BabikerAbdelA,
pubmed-author:CohenCalvin JCJ,
pubmed-author:EmerySeanS,
pubmed-author:GatellJose MJM,
pubmed-author:GirardPierre-MariePM,
pubmed-author:GrundBirgitB,
pubmed-author:LawMatthewM,
pubmed-author:LossoMarcelo HMH,
pubmed-author:NeuhausJacqueline AJA,
pubmed-author:PalfreemanAdrianA,
pubmed-author:PhillipsAndrew NAN,
pubmed-author:Strategies for Management of Antiretroviral Therapy (SMART) Study Group,
pubmed-author:WoodRobinR
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
197
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1133-44
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18476292-AIDS-Related Opportunistic Infections,
pubmed-meshheading:18476292-Adult,
pubmed-meshheading:18476292-Anti-HIV Agents,
pubmed-meshheading:18476292-CD4 Lymphocyte Count,
pubmed-meshheading:18476292-Cohort Studies,
pubmed-meshheading:18476292-Drug Administration Schedule,
pubmed-meshheading:18476292-Female,
pubmed-meshheading:18476292-HIV,
pubmed-meshheading:18476292-HIV Infections,
pubmed-meshheading:18476292-Humans,
pubmed-meshheading:18476292-Kaplan-Meier Estimate,
pubmed-meshheading:18476292-Male,
pubmed-meshheading:18476292-Middle Aged,
pubmed-meshheading:18476292-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study.
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pubmed:affiliation |
Therapeutic and Vaccine Research Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria St., Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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