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pubmed:abstractText |
Annexin-A1 (ANXA1), a glucocorticoid-regulated protein, mediates several of the anti-inflammatory actions of the glucocorticoids. Previous studies demonstrated that ANXA1 is involved in pain modulation. The current study, using ANXA1 knockout mice (ANXA1-/-), is aimed at addressing the site and mechanism of the modulatory action of ANXA1 as well as possible involvement of ANXA1 in mediating the analgesic action of glucocorticoids.
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pubmed:affiliation |
Centre for Biochemical Pharmacology, William Harvey Research Institute, St Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London, UK. s.s.ayoub@qmul.ac.uk
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