|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2008-8-19
|
|
pubmed:abstractText |
Peritubular capillary injury induces chronic hypoxia in the renal tubulointerstitium, and renal peritubular capillary dysfunction is an early event that contributes to tubulointerstitial fibrosis. Cyclosporine A (CsA) is a potent immunosuppressant and improves survival of renal allografts. However, the limitation of CsA use is chronic nephrotoxicity. A soluble, stable and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1 has been developed. We investigated whether COMP-Ang1 ameliorates CsA-induced renal injury.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/COMP-Ang1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte chemoattractant protein 1...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1460-2385
|
|
pubmed:author |
pubmed-author:JangKyu YunKY,
pubmed-author:JungYu JinYJ,
pubmed-author:KangKyung PyoKP,
pubmed-author:KimDuk HoonDH,
pubmed-author:KimWonW,
pubmed-author:KohGou YoungGY,
pubmed-author:LUOW HWH,
pubmed-author:LeeAe SinAS,
pubmed-author:LeeSang YongSY,
pubmed-author:MoonSang-OkSO,
pubmed-author:ParkSung KwangSK,
pubmed-author:SungMi JeongMJ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2784-94
|
|
pubmed:meshHeading |
pubmed-meshheading:18463324-Animals,
pubmed-meshheading:18463324-Blotting, Western,
pubmed-meshheading:18463324-Capillaries,
pubmed-meshheading:18463324-Chemokine CCL2,
pubmed-meshheading:18463324-Cyclosporine,
pubmed-meshheading:18463324-Endothelium, Vascular,
pubmed-meshheading:18463324-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18463324-Immunohistochemistry,
pubmed-meshheading:18463324-Immunosuppressive Agents,
pubmed-meshheading:18463324-In Situ Nick-End Labeling,
pubmed-meshheading:18463324-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18463324-Kidney,
pubmed-meshheading:18463324-Kidney Diseases,
pubmed-meshheading:18463324-Kidney Tubules,
pubmed-meshheading:18463324-Mice,
pubmed-meshheading:18463324-Mice, Inbred ICR,
pubmed-meshheading:18463324-Microcirculation,
pubmed-meshheading:18463324-Peptide Fragments,
pubmed-meshheading:18463324-Recombinant Fusion Proteins,
pubmed-meshheading:18463324-Regional Blood Flow,
pubmed-meshheading:18463324-Smad2 Protein,
pubmed-meshheading:18463324-Smad3 Protein,
pubmed-meshheading:18463324-Smad7 Protein
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice.
|
|
pubmed:affiliation |
Department of Internal Medicine, Chonbuk National University Medical School, 634-18, Keum-Am Dong, Jeonju, 561-712, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
