Linked Life Data

18462922

Source:http://linkedlifedata.com/resource/pubmed/id/18462922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-5-26
pubmed:abstractText
The present review paper summarizes the data available in the literature concerning prenatal exposure to dinoseb (2-sec-butyl-4,6-dinitrophenol; CAS No. 88-85-7), evaluating reported developmental toxicity in experimental animals. In particular, we have focused on the variable factors in the manifestation of the developmental toxicity of dinoseb. In this review, we showed that developmental toxicity of dinoseb was remarkably different between animal species used in experiments. Teratogenicity was detected in rats fed a diet containing dinoseb, in mice given dinoseb by gavage, intraperitoneally or subcutaneously, and in rabbits given dinoseb by gavage or dermally. Teratogenicity in rats given dinoseb by gavage was influenced by the dietary composition used in the experiments. We postulated that evaluation of the developmental toxicity after exposure by anticipated routes of human exposure would be important for risk assessment in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0890-6238
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-34
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Review of developmental toxicity of nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol.
pubmed:affiliation
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, Japan.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't