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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2008-6-30
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pubmed:abstractText |
Lipopolysaccharides (LPS) are components of Gram-negative bacteria. The cellular response from the host to LPS is mediated through stepwise interactions involving the lipopolysaccharide-binding protein (LBP), CD14, and MD-2, which produces the rearrangement of TLR4. In addition to LBP, the lipid transfer/lipopolysaccharide-binding protein gene family includes the phospholipid transfer protein (PLTP). Here we show that the intravascular redistribution of LPS from the plasma lipoprotein-free fraction toward circulating lipoproteins is delayed in PLTP-deficient mice. In agreement with earlier in vitro studies, which predicted the neutralization of the endotoxic properties of LPS when associated with lipoproteins, significant increases in the plasma concentration of proinflammatory cytokines were found in PLTP-deficient as compared with wild type mice. Similar inflammatory damage occurred in tissues from wild type and PLTP-deficient mice 24 h after one single intraperitoneal injection of LPS but with a more severe accumulation of red blood cells in glomeruli of LPS-injected PLTP-deficient mice. Complementary ex vivo experiments on isolated splenocytes from wild type and PLTP-deficient mice further supported the ability of cell-derived PLTP to prevent LPS-mediated inflammation and cytotoxicity when combined with lipoprotein acceptors. Finally, PLTP deficiency in mice led to a significant increase in LPS-induced mortality. It is concluded that increasing circulating levels of PLTP may constitute a new and promising strategy in preventing endotoxic shock.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acute-Phase Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Ly96 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Antigen 96,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipid Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/lipopolysaccharide-binding protein,
http://linkedlifedata.com/resource/pubmed/chemical/phospholipid transfer protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:AthiasAnneA,
pubmed-author:DeckertValérieV,
pubmed-author:DesrumauxCatherineC,
pubmed-author:GautierThomasT,
pubmed-author:JiangXian-ChengXC,
pubmed-author:KleinAlexisA,
pubmed-author:LagrostLaurentL,
pubmed-author:Le GuernNaigN,
pubmed-author:MassonDavidD,
pubmed-author:MonierSergeS,
pubmed-author:MontangeThomasT,
pubmed-author:OgierNicolasN,
pubmed-author:PaulCatherineC,
pubmed-author:PiardFrançoiseF,
pubmed-author:SbernaAnne-LaureAL
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18702-10
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pubmed:meshHeading |
pubmed-meshheading:18458077-Acute-Phase Proteins,
pubmed-meshheading:18458077-Animals,
pubmed-meshheading:18458077-Antigens, CD14,
pubmed-meshheading:18458077-Carrier Proteins,
pubmed-meshheading:18458077-Cytokines,
pubmed-meshheading:18458077-Endotoxemia,
pubmed-meshheading:18458077-Inflammation,
pubmed-meshheading:18458077-Inflammation Mediators,
pubmed-meshheading:18458077-Lipopolysaccharides,
pubmed-meshheading:18458077-Lymphocyte Antigen 96,
pubmed-meshheading:18458077-Membrane Glycoproteins,
pubmed-meshheading:18458077-Mice,
pubmed-meshheading:18458077-Mice, Knockout,
pubmed-meshheading:18458077-Phospholipid Transfer Proteins,
pubmed-meshheading:18458077-Spleen,
pubmed-meshheading:18458077-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice.
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pubmed:affiliation |
INSERM, Centre de Recherche-UMR866, Faculté de Médecine, Institut Fédératif de Recherche Santé-STIC, Universitéde Bourgogne, 21079 Dijon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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