Linked Life Data

1845540

Source:http://linkedlifedata.com/resource/pubmed/id/1845540

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-10-7
pubmed:abstractText
Ethanol both in vitro and in vivo has been shown to affect membrane bulk lipids and it had been previously proposed that such effects may explain sensitivity and tolerance to ethanol. There has been however, criticism of the membrane bulk lipid hypothesis and interest in the role of lipids as a site of the effects of ethanol has declined. This change in how lipids are viewed may have been premature. Several groups including work of our laboratory have shown in the past few years that ethanol has a very pronounced effect on membrane lipids but that these effects are restricted to specific domains of the membrane. This paper will discuss how ethanol affects membrane domains and mechanisms that may be involved in the regulation of lipid domains with emphasis on cholesterol domains. Discussion will also cover how lipid domains interact with protein organization and function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1358-6173
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-5
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Significance of ethanol-induced changes in membrane lipid domains.
pubmed:affiliation
VA Medical Center, GRECC, Minneapolis, MN 55417.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review