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rdf:type |
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lifeskim:mentions |
umls-concept:C0003385,
umls-concept:C0072780,
umls-concept:C0205245,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0439064,
umls-concept:C0441655,
umls-concept:C0851343,
umls-concept:C1510827,
umls-concept:C1883254,
umls-concept:C1979963,
umls-concept:C2003903
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pubmed:issue |
10
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pubmed:dateCreated |
2008-5-26
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pubmed:abstractText |
Completing a long-lasting research on 1,3-oxathiolane muscarinic ligands, we have synthesized a set of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide derivatives, containing three or four stereogenic centers. In general the compounds are very potent antagonists even if, unlike the corresponding agonists, they show modest subtype selectivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:BellucciCristinaC,
pubmed-author:BuccioniMichelaM,
pubmed-author:DeiSilviaS,
pubmed-author:FerraroniMartaM,
pubmed-author:GuandaliniLucaL,
pubmed-author:ManettiDinaD,
pubmed-author:MarucciGabriellaG,
pubmed-author:MatucciRosannaR,
pubmed-author:NesiMartaM,
pubmed-author:RomanelliMaria NovellaMN,
pubmed-author:ScapecchiSerenaS,
pubmed-author:TeodoriElisabettaE
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5490-500
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pubmed:meshHeading |
pubmed-meshheading:18455407-Animals,
pubmed-meshheading:18455407-Binding Sites,
pubmed-meshheading:18455407-CHO Cells,
pubmed-meshheading:18455407-Cells, Cultured,
pubmed-meshheading:18455407-Cricetinae,
pubmed-meshheading:18455407-Cricetulus,
pubmed-meshheading:18455407-Dose-Response Relationship, Drug,
pubmed-meshheading:18455407-Guinea Pigs,
pubmed-meshheading:18455407-Ligands,
pubmed-meshheading:18455407-Male,
pubmed-meshheading:18455407-Models, Molecular,
pubmed-meshheading:18455407-Molecular Structure,
pubmed-meshheading:18455407-Muscarinic Antagonists,
pubmed-meshheading:18455407-Pyrrolidines,
pubmed-meshheading:18455407-Rabbits,
pubmed-meshheading:18455407-Receptors, Muscarinic,
pubmed-meshheading:18455407-Stereoisomerism,
pubmed-meshheading:18455407-Structure-Activity Relationship,
pubmed-meshheading:18455407-Sulfoxides
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pubmed:year |
2008
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pubmed:articleTitle |
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.
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pubmed:affiliation |
Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi (HeteroBioLab), Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (FI), Italy. silvia.dei@unifi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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