18454146

Source:http://linkedlifedata.com/resource/pubmed/id/18454146

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021655, umls-concept:C0042333, umls-concept:C0205214, umls-concept:C0332281, umls-concept:C0455829, umls-concept:C1417064
pubmed:issue	6
pubmed:dateCreated	2008-5-29
pubmed:abstractText	We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/066786, http://linkedlifedata.com/resource/pubmed/grant/SP/04/002
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9216904
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/MC4R protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 4
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1546-1718
pubmed:author	pubmed-author:BaldingDavidD, pubmed-author:ChambersJohn CJC, pubmed-author:ElliottPaulP, pubmed-author:FroguelPhilippeP, pubmed-author:KoonerJaspal SJS, pubmed-author:LiYunY, pubmed-author:ScottJamesJ, pubmed-author:WeihuaZhangZ, pubmed-author:ZabanehDelilahD
pubmed:issnType	Electronic
pubmed:volume	40
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	716-8
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:18454146-Adiposity, pubmed-meshheading:18454146-Adult, pubmed-meshheading:18454146-Aged, pubmed-meshheading:18454146-Alleles, pubmed-meshheading:18454146-Asian Continental Ancestry Group, pubmed-meshheading:18454146-Body Mass Index, pubmed-meshheading:18454146-Case-Control Studies, pubmed-meshheading:18454146-Cohort Studies, pubmed-meshheading:18454146-European Continental Ancestry Group, pubmed-meshheading:18454146-Female, pubmed-meshheading:18454146-Genetic Linkage, pubmed-meshheading:18454146-Genetic Predisposition to Disease, pubmed-meshheading:18454146-Genetic Variation, pubmed-meshheading:18454146-Genome, Human, pubmed-meshheading:18454146-Homozygote, pubmed-meshheading:18454146-Humans, pubmed-meshheading:18454146-Insulin Resistance, pubmed-meshheading:18454146-Male, pubmed-meshheading:18454146-Middle Aged, pubmed-meshheading:18454146-Polymorphism, Single Nucleotide, pubmed-meshheading:18454146-Receptor, Melanocortin, Type 4, pubmed-meshheading:18454146-Risk Factors, pubmed-meshheading:18454146-Waist-Hip Ratio
pubmed:year	2008
pubmed:articleTitle	Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
pubmed:affiliation	Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl., London W2 1PG, UK.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't