Source:http://linkedlifedata.com/resource/pubmed/id/18453585
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2008-5-5
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| pubmed:abstractText |
T-bet and STAT4 play critical roles in helper T cell differentiation, especially for Th1 cells. However, it is still unknown about the relative importance and redundancy of T-bet and STAT4 for Th1 differentiation. It is also unknown about their independent role of T-bet and STAT4 in the regulation of allergic airway inflammation. In this study, we addressed these issues by comparing T-bet-deficient (T-bet(-/-)) mice, STAT4(-/-) mice, and T-bet- and STAT4-double-deficient (T-bet(-/-)STAT4(-/-)) mice on the same genetic background. Th1 differentiation was severely decreased in T-bet(-/-) mice and STAT4(-/-) mice as compared with that in wild-type mice, but Th1 differentiation was still observed in T-bet(-/-) mice and STAT4(-/-) mice. However, Th1 cells were hardly detected in T-bet(-/-)STAT4(-/-) mice. In contrast, the maintenance of Th17 cells was enhanced in T-bet(-/-) mice but was reduced in STAT4(-/-) mice and T-bet(-/-)STAT4(-/-) mice. In vivo, Ag-induced eosinophil and neutrophil recruitment into the airways was enhanced in T-bet(-/-) mice but was attenuated in STAT4(-/-) mice and T-bet(-/-)STAT4(-/-) mice. Ag-induced IL-17 production in the airways was also diminished in STAT4(-/-) mice and T-bet(-/-)STAT4(-/-) mice. These results indicate that STAT4 not only plays an indispensable role in T-bet-independent Th1 differentiation but also is involved in the maintenance of Th17 cells and the enhancement of allergic airway inflammation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0022-1767
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| pubmed:author |
pubmed-author:FujiwaraMichioM,
pubmed-author:FurutaShunsukeS,
pubmed-author:HiroseKoichiK,
pubmed-author:IkedaKeiK,
pubmed-author:IwamotoItsuoI,
pubmed-author:KagamiShin-ichiroS,
pubmed-author:NakajimaHiroshiH,
pubmed-author:SaitoYasushiY,
pubmed-author:SutoAkiraA,
pubmed-author:TamachiTomohiroT,
pubmed-author:WatanabeNorihikoN
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| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
180
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6656-62
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| pubmed:meshHeading |
pubmed-meshheading:18453585-Animals,
pubmed-meshheading:18453585-Bronchial Hyperreactivity,
pubmed-meshheading:18453585-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18453585-Cell Differentiation,
pubmed-meshheading:18453585-Cell Proliferation,
pubmed-meshheading:18453585-Cytokines,
pubmed-meshheading:18453585-Flow Cytometry,
pubmed-meshheading:18453585-Hypersensitivity,
pubmed-meshheading:18453585-Interleukin-17,
pubmed-meshheading:18453585-Mice,
pubmed-meshheading:18453585-Mice, Mutant Strains,
pubmed-meshheading:18453585-Ovalbumin,
pubmed-meshheading:18453585-Pneumonia,
pubmed-meshheading:18453585-STAT4 Transcription Factor,
pubmed-meshheading:18453585-T-Box Domain Proteins,
pubmed-meshheading:18453585-T-Lymphocyte Subsets,
pubmed-meshheading:18453585-Th1 Cells,
pubmed-meshheading:18453585-Th2 Cells
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| pubmed:year |
2008
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| pubmed:articleTitle |
Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation.
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| pubmed:affiliation |
Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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