Linked Life Data

18452039

Source:http://linkedlifedata.com/resource/pubmed/id/18452039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-5-23
pubmed:abstractText
In the search of new antileishmanial drugs from marine resources, we have investigated Actinopyga lecanora, a coral reef sea cucumber, for its in vitro and in vivo activities. Methanol extract and n-butanol fraction of A. lecanora exhibited excellent Leishmania donovani inhibition. Among the two glycosides isolated from n-butanol fraction, holothurin B (2) displayed excellent in vitro and moderate in vivo leishmanicidal activity, whereas holothurin A (1) revealed only moderate action. These findings provide an important marine lead toward the development of new antileishmanial drugs and necessitate the further exploration of rich and diverse marine resources for more potent bioactive molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0932-0113
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Antileishmanial activity in vitro and in vivo of constituents of sea cucumber Actinopyga lecanora.
pubmed:affiliation
Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226001, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't