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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2008-6-2
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pubmed:abstractText |
An unbiased conditioned place preference paradigm and the microdialysis technique was used to evaluate the effect of (+)-morphine pretreatment on the conditioned place preference produced by (-)-morphine and the increased release of the dopamine produced by mu-opioid ligand endomorphin-1, respectively, in the posterior nucleus accumbens shell of the male CD rat. (-)-Morphine (2.5-10 microg) microinjected into the posterior nucleus accumbens shell dose-dependently produced the conditioned place preference. Pretreatment with (+)-morphine (0.1-10 pg) given into the posterior accumbens shell for 45 min dose-dependently attenuated the conditioned place preference produced by (-)-morphine (5 microg) given into the same posterior accumbens shell. However, higher doses of (+)-morphine (0.1 and 1 ng) were less effective in attenuating the (-)-morphine-produced conditioned place preference. Thus, like given systemically, (+)-morphine given into the posterior nucleus accumbens shell also induces a U-shaped dose-response curve for attenuating the (-)-morphine-produced conditioned place preference. Microinjection of mu-opioid agonist endomorphin-1 (1-10 microg) given into the ventral tegmental area dose-dependently increased the release of the extracellular dopamine in the posterior nucleus accumbens shell in the urethane-anesthetized rats. The increased dopamine caused by endomorphin-1 (10 microg) was completed blocked by the (+)-morphine (10 pg) pretreatment given into ventral tegmental area. It is concluded that (+)-morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated increase of extracellular dopamine in the posterior nucleus accumbens shell of the rat.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18448094-12177217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18448094-12195028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18448094-12907414,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18448094-9593848
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
587
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18448094-Analgesics, Opioid,
pubmed-meshheading:18448094-Anesthesia,
pubmed-meshheading:18448094-Animals,
pubmed-meshheading:18448094-Chromatography, High Pressure Liquid,
pubmed-meshheading:18448094-Conditioning, Operant,
pubmed-meshheading:18448094-Dopamine,
pubmed-meshheading:18448094-Dose-Response Relationship, Drug,
pubmed-meshheading:18448094-Electrochemistry,
pubmed-meshheading:18448094-Male,
pubmed-meshheading:18448094-Microinjections,
pubmed-meshheading:18448094-Morphine,
pubmed-meshheading:18448094-Naloxone,
pubmed-meshheading:18448094-Narcotic Antagonists,
pubmed-meshheading:18448094-Nucleus Accumbens,
pubmed-meshheading:18448094-Oligopeptides,
pubmed-meshheading:18448094-Rats,
pubmed-meshheading:18448094-Receptors, Opioid, mu,
pubmed-meshheading:18448094-Stereoisomerism,
pubmed-meshheading:18448094-Ventral Tegmental Area
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pubmed:year |
2008
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pubmed:articleTitle |
(+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat.
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pubmed:affiliation |
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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