Linked Life Data

18440283

Source:http://linkedlifedata.com/resource/pubmed/id/18440283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-10-20
pubmed:abstractText
Our daily life not only involves calm, resting states but is filled with perturbations that induce active conditions, such as movements, eating, and communicating. During such active periods, cardiorespiratory regulation must be adjusted for bodily demands, which differ from those during resting states, by modulating or resetting baseline levels. To explore neural mechanisms of state-dependent adjustments of central autonomic regulation, we recently focused on the following two states: 1), stress-induced defense (fight-or-flight) responses, because stressors induce both cognitive, emotional, and behavioral changes and autonomic alterations, and 2), sleep/wake differences. Basal respiration and respiratory reflex regulation significantly differ during waking and sleep states. In this review, we will summarize our recent findings with orexin knockout and orexin neuron-ablated mice to determine possible contributions of orexin, a hypothalamic neuropeptide, to state-dependent adjustments of central autonomic regulation. The diversity of synaptic control of cardiovascular and respiratory neurons appears to be necessary for animals to adapt to ever-changing life circumstances and behavioral states. The orexin system likely functions as one essential modulator for coordinating circuits controlling autonomic functions and behaviors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-7484
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-6
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Emotional and state-dependent modification of cardiorespiratory function: role of orexinergic neurons.
pubmed:affiliation
Department of Molecular & Integrative Physiology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. kuwaki@faculty.chiba-u.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't